Targeting Rac and Cdc42 GEFs in Metastatic Cancer
نویسندگان
چکیده
منابع مشابه
Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs
Rho family GTPases, including RhoA, Rac1, and Cdc42 as the most studied members, are master regulators of actin cytoskeletal organization. Rho GTPases control various aspects of the nervous system and are associated with a number of neuropsychiatric and neurodegenerative diseases. The activity of Rho GTPases is controlled by two families of regulators, guanine nucleotide exchange factors (GEFs)...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.00201